Antineoplastics

Anticancer drugs are divided into:

  • Cytotoxic
    • They do not differentiate between host and tumor cells
  • Targeted
    • They are targetted

Cytotoxic drugs

  • They kill rapidly-dividing cells without differentiation
  • Lead to:
    • Bone Marrow suppression
    • GIT
      • Cells of GIT are constantly replaced, when this doesn’t occur diarrhea from mucositis
    • Alopecia - Hair follicle
    • Purines from cells killed -> Purine release -> Xanthine -> Uric acid : Hyperuricemia
    • Secondary Leukemia

Cell Cycle inhibitors

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